Marie Darrieussecq was born on January 3, 1969. She was raised in a small village in the Basque Country.

While finishing her PhD in French Literature, she wrote her first novel, Truismes (Pig Tales) which was published in September 1996 by Paul Otchakovsky-Laurens (POL), who have published all her subsequent novels as well. After the success of Truismes, Darrieussecq decided to quit her teaching position at the University of Lille to concentrate on writing her novels. Her first husband was a mathematician, her second is an astrophysicist. She gave birth to a son in 2001 and to a daughter in 2004.

She endorsed Ségolène Royal's candidacy during the French Presidential Elections of 2007.