Michael Talbot was born in Grand Rapids, Michigan in 1953. As a young man, he moved to New York City, where he pursued a career as a freelance writer, publishing articles in Omni, The Village Voice, and others, often exploring the confluence between science and the spiritual.

Talbot published his first novel, The Delicate Dependency: A Novel of the Vampire Life as an Avon paperback original in 1982; though never reprinted, it is regarded a classic of the genre, frequently appearing on lists of the best vampire novels ever written, and secondhand copies have long been expensive and hard to find. His other horror titles, both cult classics, are The Bog (1986) and Night Things (1988).

But despite the popularity of his fiction among horror fans, it was for his nonfiction that Talbot was best known, much of it focusing on new age concepts, mysticism, and the paranormal. Arguably his most famous and most significant is The Holographic Universe (1991), which examines the increasingly accepted theory that the entire universe is a hologram; the book remains in print and highly discussed today.

Michael Talbot died of leukemia in 1992 at age 38.